Metagenomics Data Analysis Services

AMR & Pathogen Virulence Factor Profiling

Safeguard health with precise identification of resistance genes and virulence determinants across complex samples. Dawn of Bioinformatics Ltd. offers dedicated antimicrobial resistance (AMR) and virulence factor profiling services to assess the resistome and pathogenic potential within any microbiome. Using curated databases (CARD, ResFinder, VFDB) and high stringency read mapping, our DawniLab experts detect known and novel resistance mechanisms, track mobile genetic elements, and quantify horizontal gene transfer risk, delivering high confidence results that streamline clinical surveillance, outbreak tracking, and phage therapy development.

AMR & Pathogen Virulence Factor Profiling

Overview

Dawn of Bioinformatics Ltd. performs dedicated antimicrobial resistance and virulence factor profiling to assess the full resistome and pathogenic potential present in any microbiome sample. Using stringent read mapping against manually curated databases and rigorous mutation analysis, we detect known resistance determinants, identify novel alleles, and link them to mobile genetic elements that indicate a high risk of horizontal gene transfer. This service by DawniLab supplies hospitals, public health agencies, and research groups with high confidence, publication grade surveillance data that can guide infection control, outbreak tracing, and phage-based interventions.

Key Features

✓ Resistome profiling against CARD, ResFinder, and custom built mutation panels.
✓ Virulence factor annotation (VFDB, PATRIC) with pathogenicity island genotyping.
✓ Mobility element detection (plasmid replicons, integrons, transposases) to assess transfer potential.
✓ Quantitative abundance matrices, richness, and diversity indexing for resistome/virulome comparisons.

Demo & Results

We screened 300 hospital wastewater metagenomes and uncovered 45 novel beta lactamase variants located on conjugative plasmids. The early warning enabled the infection control team to trace an outbreak source to a single ward, where targeted disinfection halted further transmission within 72 hours.

Frequently Asked Questions